Pattern variability in a computational model of respiratory rhythm generation
نویسندگان
چکیده
منابع مشابه
Respiratory rhythm generation in vivo.
The cellular and circuit mechanisms generating the rhythm of breathing in mammals have been under intense investigation for decades. Here, we try to integrate the key discoveries into an updated description of the basic neural processes generating respiratory rhythm under in vivo conditions.
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THERE HAVE BEEN very significant advances in our understanding of how respiratory rhythm is generated in mammals [see Feldman and Del Negro (2) for review]. This has provided the fundamental background on which to pursue investigations into how the system develops during the perinatal period. Respiratory rhythmogenesis is not only essential for postnatal survival but it is required in utero. Fa...
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Activities of the phrenic and internal intercostal nerves show that the central nervous rhythm of respiration consists of 3 phases: inspiratory, postinspiratory and expiratory. The discharge patterns of medullary respiratory neurones of the anaesthetized, paralysed cat can be correlated with these phases of the central respiratory cycle, and the postsynaptic activity of individual cells can be ...
متن کاملRespiratory rhythm generation: triple oscillator hypothesis
Breathing is vital for survival but also interesting from the perspective of rhythm generation. This rhythmic behavior is generated within the brainstem and is thought to emerge through the interaction between independent oscillatory neuronal networks. In mammals, breathing is composed of three phases - inspiration, post-inspiration, and active expiration - and this article discusses the concep...
متن کاملEffects of glycinergic inhibition failure on respiratory rhythm and pattern generation.
Inhibitory interactions between neurons of the respiratory network are involved in rhythm generation and pattern formation. Using a computational model of brainstem respiratory networks, we investigated the possible effects of suppressing glycinergic inhibition on the activity of different respiratory neuron types. Our study revealed that progressive suppression of glycinergic inhibition affect...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2012
ISSN: 1471-2202
DOI: 10.1186/1471-2202-13-s1-p139